How does this fit into my life? Well, I'm basically transitioning from a maker to a manager now that I'm the PI of my own group. Instead of spending most of my days in 3-4 hour chunks of either coding or being deep in analysis, I am finding most of my days interrupted with at least a couple of meetings, which make it almost impossible to actually accomplish any "making". This realization is important, because I don't want to end up being only a manager of other makers. As scientists get promoted they tend to flow from making to managing, but different individuals succeed to different extents at maintaining a balance. Put another way, I want to keep spending a large fraction of my time with an xterm and an emacs buffer open, rather than my email client and a Word document (ugh).
I obviously have to spend a reasonable amount of time meeting with people, so how do I strike the balance I want? What Graham describes from his younger days, and what I've seen a lot of scientists do is basically work two full days every day: 9-5ish as a manager and then 9PM-2AM (or whatever) coding, analyzing data, or whatever. I'm not quite ready to work that much, so what I've resolved to do (we'll see how it goes) is to actually schedule half-day chunks into my calendar for "making" when I won't be free to accept meetings with anyone else. I'll close my door, not answer the phone, and focus on a project in that time.
Wish me luck!